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Human mutations highlight an intersubunit cation–π bond that stabilizes the closed but not open or inactivated states of TRPV channels

An adequate response of a living cell to the ever-changing environment requires integration of numerous sensory inputs. In many cases, it can be achieved even at the level of a single receptor molecule. Polymodal transient receptor potential (TRP) channels have been shown to integrate mechanical, ch...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Teng, Jinfeng, Anishkin, Andriy, Kung, Ching, Blount, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511060/
https://ncbi.nlm.nih.gov/pubmed/31010928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820673116
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