MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and quantified the phosphorylation of 17 kinases using xMAP assa...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Kotelnikova, Ekaterina, Kiani, Narsis A., Messinis, Dimitris, Pertsovskaya, Inna, Pliaka, Vicky, Bernardo-Faura, Marti, Rinas, Melanie, Vila, Gemma, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Sakellaropoulos, Theodore, Faigle, Wolfgang, Silberberg, Gilad, Masso, Mar, Stridh, Pernilla, Behrens, Janina, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Alexopoulos, Leonidas G., Saez-Rodriguez, Julio, Tegner, Jesper, Villoslada, Pablo
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2019
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510997/
https://ncbi.nlm.nih.gov/pubmed/31004050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818347116
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