Telomere DNA G-quadruplex folding within actively extending human telomerase

Telomerase reverse transcribes short guanine (G)-rich DNA repeat sequences from its internal RNA template to maintain telomere length. G-rich telomere DNA repeats readily fold into G-quadruplex (GQ) structures in vitro, and the presence of GQ-prone sequences throughout the genome introduces challeng...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Jansson, Linnea I., Hentschel, Jendrik, Parks, Joseph W., Chang, Terren R., Lu, Cheng, Baral, Rishika, Bagshaw, Clive R., Stone, Michael D.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510993/
https://ncbi.nlm.nih.gov/pubmed/31019071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814777116
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