Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer()

Castration-resistant prostate cancer remains as an incurable disease. Exploiting DNA damage repair defects via inhibition of poly (ADP-ribose) polymerase (PARP) is becoming an attractive therapeutic option. The TOPARP-A clinical trial demonstrated that the PARP inhibitor olaparib may be an effective...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Lombard, Alan P, Liu, Chengfei, Armstrong, Cameron M, D'Abronzo, Leandro S, Lou, Wei, Chen, Hongwu, Dall'Era, Marc, Ghosh, Paramita M, Evans, Christopher P, Gao, Allen C
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2019
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510951/
https://ncbi.nlm.nih.gov/pubmed/31075528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.04.007
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