Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ

The proinflammatory cytokine interferon-γ (IFN-γ) has been implicated in human hematopoietic stem and progenitor cell (HSPC) depletion in immune-mediated bone marrow failure syndromes. We show that IFN-γ specifically prevents full engagement of thrombopoietin (TPO), a primary positive regulator of H...

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Veröffentlicht in:Blood
Hauptverfasser: Alvarado, Luigi J., Huntsman, Heather D., Cheng, Hai, Townsley, Danielle M., Winkler, Thomas, Feng, Xingmin, Dunbar, Cynthia E., Young, Neal S., Larochelle, Andre
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509545/
https://ncbi.nlm.nih.gov/pubmed/30803992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-11-884486
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