Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice

The myelodysplastic syndromes (MDS) represent a group of clonal disorders that result in ineffective hematopoiesis and are associated with an increased risk of transformation into acute leukemia. MDS arises from hematopoietic stem cells (HSCs); therefore, successful elimination of MDS HSCs is an imp...

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Bibliographic Details
Published in:Blood
Main Authors: Pang, Wendy W., Czechowicz, Agnieszka, Logan, Aaron C., Bhardwaj, Rashmi, Poyser, Jessica, Park, Christopher Y., Weissman, Irving L., Shizuru, Judith A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2019
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509544/
https://ncbi.nlm.nih.gov/pubmed/30745302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-06-858159
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