RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination

The proficiency of cancer cells to repair DNA double-strand breaks (DSBs) by homologous recombination (HR) is a key determinant in predicting response to targeted therapies such as PARP inhibitors. The RAD51 paralogs work as multimeric complexes and act downstream of BRCA1 to facilitate HR. Numerous...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Baldock, Robert A., Pressimone, Catherine A., Baird, Jared M., Khodakov, Anton, Luong, Thong T., Grundy, McKenzie K., Smith, Chelsea M., Karpenshif, Yoav, Bratton-Palmer, Dominique S., Garcin, Edwige B., Gon, Stéphanie, Modesti, Mauro, Bernstein, Kara A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508892/
https://ncbi.nlm.nih.gov/pubmed/30836272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.02.008
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