A310 THE INHIBITION OF PTP1B REVERSES IMPAIRED VAGAL AFFERENT SENSITIVITY CAUSED BY DIET-INDUCED OBESITY, REDUCING NITRIC OXIDE AND 2 PORE DOMAIN K(+) CONDUCTANCE

BACKGROUND: We have demonstrated that diet-induced obesity impairs vagal afferents and that the effects of high concentrations of leptin on vagal afferents in vitro, mimic the effects of obesity. One of downstream molecules in leptin signaling is protein tyrosine phosphatase 1B (PTP1B), which plays...

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Vydáno v:J Can Assoc Gastroenterol
Hlavní autoři: Park, S, Beyak, M J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Poster Presentations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507739/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy008.311
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