N-Methyl-N-Nitrosourea-Induced Photoreceptor Degeneration Is Inhibited by Nicotinamide via the Blockade of Upstream Events before the Phosphorylation of Signalling Proteins

N-methyl-N-nitrosourea (MNU), a known carcinogen, is generally used in animal models to chemically induce photoreceptor degeneration. It has been reported that nicotinamide (NAM) exerts a protective effect on MNU-induced photoreceptor degeneration. We investigated the molecular mechanisms on MNU-ind...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Sugano, Eriko, Tabata, Kitako, Takezawa, Tsubasa, Shiraiwa, Raki, Muraoka, Hiroki, Metoki, Tomomi, Kudo, Asaka, Iwama, Yuki, Nakazawa, Mitsuru, Tomita, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507250/
https://ncbi.nlm.nih.gov/pubmed/31179317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3238719
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