Genes with High Network Connectivity Are Enriched for Disease Heritability

Recent studies have highlighted the role of gene networks in disease biology. To formally assess this, we constructed a broad set of pathway, network, and pathway+network annotations and applied stratified LD score regression to 42 diseases and complex traits (average N = 323K) to identify enriched...

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Vydáno v:Am J Hum Genet
Hlavní autoři: Kim, Samuel S., Dai, Chengzhen, Hormozdiari, Farhad, van de Geijn, Bryce, Gazal, Steven, Park, Yongjin, O’Connor, Luke, Amariuta, Tiffany, Loh, Po-Ru, Finucane, Hilary, Raychaudhuri, Soumya, Price, Alkes L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506868/
https://ncbi.nlm.nih.gov/pubmed/31051114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.03.020
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