Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx

Aldosterone contributes to end-organ damage in heart failure and chronic kidney disease. Mineralocorticoid-receptor inhibitors limit activation of the receptor by aldosterone and slow disease progression, but side effects, including hyperkalemia, limit their clinical use. Damage to the endothelial g...

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Foilsithe in:Kidney Int
Main Authors: Butler, Matthew J., Ramnath, Raina, Kadoya, Hiroyuki, Desposito, Dorinne, Riquier-Brison, Anne, Ferguson, Joanne K., Onions, Karen L., Ogier, Anna S., ElHegni, Hesham, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Peti-Peterdi, Janos, Satchell, Simon C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506575/
https://ncbi.nlm.nih.gov/pubmed/30389198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.08.024
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