Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx

Aldosterone contributes to end-organ damage in heart failure and chronic kidney disease. Mineralocorticoid-receptor inhibitors limit activation of the receptor by aldosterone and slow disease progression, but side effects, including hyperkalemia, limit their clinical use. Damage to the endothelial g...

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Publicado en:Kidney Int
Autores principales: Butler, Matthew J., Ramnath, Raina, Kadoya, Hiroyuki, Desposito, Dorinne, Riquier-Brison, Anne, Ferguson, Joanne K., Onions, Karen L., Ogier, Anna S., ElHegni, Hesham, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Peti-Peterdi, Janos, Satchell, Simon C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506575/
https://ncbi.nlm.nih.gov/pubmed/30389198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2018.08.024
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