SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

Alternative lengthening of telomeres, or ALT, is a recombination-based process that maintains telomeres to render some cancer cells immortal. The prevailing view is that ALT is inhibited by heterochromatin because heterochromatin prevents recombination. To test this model, we used telomere-specific...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Gauchier, Mathilde, Kan, Sophie, Barral, Amandine, Sauzet, Sandrine, Agirre, Eneritz, Bonnell, Erin, Saksouk, Nehmé, Barth, Teresa K., Ide, Satoru, Urbach, Serge, Wellinger, Raymund J., Luco, Reini F., Imhof, Axel, Déjardin, Jérôme
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506250/
https://ncbi.nlm.nih.gov/pubmed/31086817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav3673
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