Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo

There is a paucity of efficacious new compounds to treat neuropsychiatric disorders. We present a novel approach to neuropsychiatric drug discovery based on high-content characterization of druggable signaling network responses at the single-cell level in patient-derived lymphocytes ex vivo. Primary...

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Vydáno v:Sci Adv
Hlavní autoři: Lago, Santiago G., Tomasik, Jakub, van Rees, Geertje F., Steeb, Hannah, Cox, David A., Rustogi, Nitin, Ramsey, Jordan M., Bishop, Joshua A., Petryshen, Tracey, Haggarty, Stephen J., Vázquez-Bourgon, Javier, Papiol, Sergi, Suarez-Pinilla, Paula, Crespo-Facorro, Benedicto, van Beveren, Nico J., Bahn, Sabine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506238/
https://ncbi.nlm.nih.gov/pubmed/31086815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau9093
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