Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological malignancies. It is detected in 10% of myeloproliferative neoplasms, 4–5% of myelodysplastic syndromes, and 1–2% of acute myeloid leukaemia. Recurrent, non-random occurrenc...

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Publicado no:Sci Rep
Main Authors: Ku, Matthew, MacKinnon, Ruth N., Wall, Meaghan, Narayan, Nisha, Walkley, Carl, Cheng, Heung-Chin, Campbell, Lynda J., Purton, Louise E., Nandurkar, Harshal
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505535/
https://ncbi.nlm.nih.gov/pubmed/31065022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43373-6
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