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Rolapitant Is a Reversible Inhibitor of CYP2D6
Rolapitant [(Varubi), 5S,8S)-8-[[(1R)-1-[3,5 bis(trifluoromethyl phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one] is a high-affinity NK1 receptor antagonist that was approved in September 2015 as a treatment for nausea and vomiting caused by chemotherapy. In vivo rolapitant moderately...
Guardat en:
| Publicat a: | Drug Metab Dispos |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505376/ https://ncbi.nlm.nih.gov/pubmed/30952677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.085928 |
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