Rolapitant Is a Reversible Inhibitor of CYP2D6

Rolapitant [(Varubi), 5S,8S)-8-[[(1R)-1-[3,5 bis(trifluoromethyl phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one] is a high-affinity NK1 receptor antagonist that was approved in September 2015 as a treatment for nausea and vomiting caused by chemotherapy. In vivo rolapitant moderately...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Glass, Sarah M., Leddy, Sabrina M., Orwin, Michael C., Miller, Garret P., Furge, Kyle A., Furge, Laura Lowe
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505376/
https://ncbi.nlm.nih.gov/pubmed/30952677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.085928
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