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MiR-20a-5p regulates gemcitabine chemosensitivity by targeting RRM2 in pancreatic cancer cells and serves as a predictor for gemcitabine-based chemotherapy

Ribonucleotide reductase subunit M2 (RRM2) acts as an important gemcitabine resistance-related gene in pancreatic cancer (PC). Here, we aimed to investigate the potential microRNA that regulates gemcitabine chemosensitivity by targeting RRM2 and explores the clinical significance of candidate miRNA...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biosci Rep
Hauptverfasser: Lu, Huimin, Lu, Shan, Yang, Dujiang, Zhang, Ling, Ye, Jun, Li, Mao, Hu, Weiming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504660/
https://ncbi.nlm.nih.gov/pubmed/30777929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181374
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