Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Silencing of the somatic cell-type specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell identity, we performed a reprogramming screen using inhibitors of chromatin factors. Here we identify acetyl-lysine competitive inhibitors targeting the...

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Pubblicato in:Nat Chem Biol
Autori principali: Ebrahimi, Ayyub, Sevinç, Kenan, Sevinç, Gülben Gürhan, Cribbs, Adam P., Philpott, Martin, Uyulur, Fırat, Morova, Tunç, Dunford, James E., Göklemez, Sencer, Arı, Şule, Oppermann, Udo, Onder, Tamer T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504645/
https://ncbi.nlm.nih.gov/pubmed/30962627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0264-z
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