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Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E oligomers

Apolipoprotein E (apoE) is an essential protein in lipid and cholesterol metabolism. Although the three common isoforms in humans differ only at two sites, their consequences in Alzheimer’s disease (AD) are dramatically different: only the ε4 allele is a major genetic risk factor for late-onset Alzh...

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Bibliografiske detaljer
Udgivet i:J Am Soc Mass Spectrom
Main Authors: Wang, Hanliu, Eschweiler, Joseph, Cui, Weidong, Zhang, Hao, Frieden, Carl, Ruotolo, Brandon T., Gross, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504607/
https://ncbi.nlm.nih.gov/pubmed/30887458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-019-02148-z
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