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Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E oligomers
Apolipoprotein E (apoE) is an essential protein in lipid and cholesterol metabolism. Although the three common isoforms in humans differ only at two sites, their consequences in Alzheimer’s disease (AD) are dramatically different: only the ε4 allele is a major genetic risk factor for late-onset Alzh...
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| Publicat a: | J Am Soc Mass Spectrom |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6504607/ https://ncbi.nlm.nih.gov/pubmed/30887458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-019-02148-z |
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