MARK3-mediated phosphorylation of ARHGEF2 couples the actin and tubulin cytoskeletons to establish cell polarity

The PAR-1-MARK pathway controls cell polarity through the phosphorylation of microtubule-associated proteins. The Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which activates the ras homolog family member A (RHOA), is anchored to the microtubule network and sequestered in an inhibited sta...

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Опубликовано в: :Sci Signal
Главные авторы: Sandí, María-José, Marshall, Christopher B., Balan, Marc, Coyaud, Étienne, Zhou, Ming, Monson, Daniel M., Ishiyama, Noboru, Chandrakumar, Arun A., La Rose, José, Couzens, Amber L., Gingras, Anne-Claude, Raught, Brian, Xu, Wei, Ikura, Mitsuhiko, Morrison, Deborah K., Rottapel, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504561/
https://ncbi.nlm.nih.gov/pubmed/29089450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan3286
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