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The Absence of SIRT3 and SIRT5 Promotes the Acetylation of Lens Proteins and Improves the Chaperone Activity of α-Crystallin in Mouse Lenses
Acetylation of lysine residues occurs in lens proteins. Previous studies have shown an improvement in the chaperone activity of αA-crystallin upon acetylation. Sirtuins are NAD(+)-dependent enzymes that can deacylate proteins. The roles of sirtuins in regulating the acetylation of lens proteins and...
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| Опубликовано в: : | Exp Eye Res |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6504558/ https://ncbi.nlm.nih.gov/pubmed/30849386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2019.02.024 |
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