Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of hearing. In contrast, the adult vestibular system can produce new hair cells in response to damage, or by reprogramming of supporting cells with the hair cell transcription factor Atoh1. We used RNA-seq and AT...

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Bibliographic Details
Published in:eLife
Main Authors: Jen, Hsin-I, Hill, Matthew C, Tao, Litao, Sheng, Kuanwei, Cao, Wenjian, Zhang, Hongyuan, Yu, Haoze V, Llamas, Juan, Zong, Chenghang, Martin, James F, Segil, Neil, Groves, Andrew K
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504235/
https://ncbi.nlm.nih.gov/pubmed/31033441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44328
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