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Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism
Vascular pruning is crucial for normal development, but its underlying mechanisms are poorly understood. Here, we report that retinal vascular pruning is controlled by the oxygen-sensing mechanism in local astrocytes. Oxygen sensing is mediated by prolyl hydroxylase domain proteins (PHDs), which use...
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| Publicado no: | Development |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503987/ https://ncbi.nlm.nih.gov/pubmed/30910827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.175117 |
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