Endothelial cell autonomous role of Akt1: Regulation of vascular tone and ischemia-induced arteriogenesis

OBJECTIVE: The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, raises the possibility of cell-type dependent Akt1-dri...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Lee, Monica Y., Gamez-Mendez, Ana, Zhang, Jiasheng, Zhuang, Zhenwu, Vinyard, David J., Kraehling, Jan, Velazquez, Heino, Brudvig, Gary W., Kyriakides, Themis R., Simons, Michael, Sessa, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503971/
https://ncbi.nlm.nih.gov/pubmed/29449333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.310748
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