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CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues
Circadian locomotor output cycles kaput (CLOCK) is a transcription factor that activates transcription of clock-controlled genes by heterodimerizing with BMAL1 and binding to E-box elements on DNA. Although several phosphorylation sites on CLOCK have already been identified, this study characterizes...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995495/ https://ncbi.nlm.nih.gov/pubmed/29588368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000773 |
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