The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

The elaboration of polarity is central to organismal development and to the maintenance of functional epithelia. Among the controls determining polarity are the PAR proteins, PAR6, aPKCι and PAR3, regulating both known and unknown effectors. Here, we identify FARP2 as a ‘RIPR’ motif-dependent partne...

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Vydáno v:J Cell Sci
Hlavní autoři: Elbediwy, Ahmed, Zhang, Yixiao, Cobbaut, Mathias, Riou, Philippe, Tan, Ray S., Roberts, Selene K., Tynan, Chris, George, Roger, Kjaer, Svend, Martin-Fernandez, Marisa L., Thompson, Barry J., McDonald, Neil Q., Parker, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2019
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503954/
https://ncbi.nlm.nih.gov/pubmed/30872454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.223743
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