Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates

[Image: see text] The enzyme 4-oxalocrotonate tautomerase (4-OT) exploits an N-terminal proline as main catalytic residue to facilitate several promiscuous C–C bond-forming reactions via enzyme-bound enamine intermediates. Here we show that the active site of this enzyme can give rise to further syn...

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Bibliografiske detaljer
Udgivet i:ACS Catal
Main Authors: Guo, Chao, Saifuddin, Mohammad, Saravanan, Thangavelu, Sharifi, Masih, Poelarends, Gerrit J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503466/
https://ncbi.nlm.nih.gov/pubmed/31080691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b00780
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