Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

BACKGROUND: Ovarian carcinomas presenting homologous recombination deficiency (HRD), which is observed in about 50% of cases, are more sensitive to platinum and PARP inhibitor therapies. Although platinum resistant disease has a low chance to be responsive to platinum-based chemotherapy, a set of pa...

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Pubblicato in:BMC Cancer
Autori principali: da Costa, Alexandre A. B. A., do Canto, Luisa M., Larsen, Simon Jonas, Ribeiro, Adriana Regina Gonçalves, Stecca, Carlos Eduardo, Petersen, Annabeth Høgh, Aagaard, Mads M., de Brot, Louise, Baumbach, Jan, Baiocchi, Glauco, Achatz, Maria Isabel, Rogatto, Silvia Regina
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503431/
https://ncbi.nlm.nih.gov/pubmed/31060523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5622-4
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