Increased Levels of Genomic Instability and Mutations in Homologous Recombination Genes in Locally Advanced Rectal Carcinomas

Pre-operative 5-fluoracil-based chemoradiotherapy (nCRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Patients with pathological complete response (pCR–0% of tumor cells in the surgical specimen after nCRT) have better overall survival and lower risk of recurren...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: do Canto, Luisa Matos, Larsen, Simon J., Catin Kupper, Bruna E., Begnami, Maria Dirlei Ferreira de Souza, Scapulatempo-Neto, Cristóvam, Petersen, Annabeth Høgh, Aagaard, Mads M., Baumbach, Jan, Aguiar, Samuel, Rogatto, Silvia R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527873/
https://ncbi.nlm.nih.gov/pubmed/31192117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00395
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