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Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer(65)Parkin reducing its calpain-cleavage
Mitochondrial impairment and calcium (Ca(++)) dyshomeostasis are associated with Parkinson’s disease (PD). When intracellular ATP levels are lowered, Ca(++)-ATPase pumps are impaired causing cytoplasmic Ca(++) to be elevated and calpain activation. Little is known about the effect of calpain activat...
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| Publicado no: | Biochim Biophys Acta Mol Basis Dis |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6502656/ https://ncbi.nlm.nih.gov/pubmed/30796971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.02.016 |
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