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Recombinant hepatitis E virus genomes infectious for primates: Importance of capping and discovery of a cis-reactive element

Hepatitis E virus recombinant genomes transcribed in vitro from two cDNA clones differing by two nucleotides were infectious for chimpanzees. However, one cDNA clone encoded a virus that was attenuated for chimpanzees and unable to infect rhesus monkeys. The second cDNA clone encoded a virus that in...

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Autors principals: Emerson, S. U., Zhang, M., Meng, X.-J., Nguyen, H., St. Claire, M., Govindarajan, S., Huang, Y. K., Purcell, R. H.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC65019/
https://ncbi.nlm.nih.gov/pubmed/11742081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251555098
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