The Open Reading Frame 3 Gene of Hepatitis E Virus Contains a cis-Reactive Element and Encodes a Protein Required for Infection of Macaques

An infectious cDNA clone of hepatitis E virus was mutated in order to prevent synthesis of either open reading frame 2 (ORF2) protein or ORF3 protein. HuH-7 cells transfected with an ORF2-null mutant produced ORF3, and those transfected with an ORF3-null mutant produced ORF2. Silent mutations introd...

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Bibliographic Details
Main Authors: Graff, Judith, Nguyen, Hanh, Yu, Claro, Elkins, William R., Claire, Marisa St., Purcell, Robert H., Emerson, Suzanne U.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112134/
https://ncbi.nlm.nih.gov/pubmed/15890906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.6680-6689.2005
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