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Dynamic Kinetic Resolution of Aldehydes by Hydroacylation
We report a dynamic kinetic resolution (DKR) of chiral 4-pentenals by olefin hydroacylation. A primary amine racemizes the aldehyde substrate via enamine formation and hydrolysis. Then, a cationic Rh-catalyst promotes hydroacylation to generate α,γ-disubstituted cyclopentanones with high enantio- an...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6501835/ https://ncbi.nlm.nih.gov/pubmed/30740841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900545 |
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