Locally translated mTOR controls axonal local translation in nerve injury

How is protein synthesis initiated locally in neurons? We found that mTOR was activated and then upregulated in injured axons, owing to local translation of mTOR mRNA. This mRNA was transported into axons by the cell size regulating RNA-binding protein nucleolin. Furthermore, mTOR controlled local t...

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I publikationen:Science
Huvudupphovsmän: Terenzio, Marco, Koley, Sandip, Samra, Nitzan, Rishal, Ida, Zhao, Qian, Sahoo, Pabitra K., Urisman, Anatoly, Marvaldi, Letizia, Oses-Prieto, Juan A., Forester, Craig, Gomes, Cynthia, Kalinski, Ashley L., Di Pizio, Agostina, Doron-Mandel, Ella, Perry, Rotem Ben-Tov, Koppel, Indrek, Twiss, Jeffery L., Burlingame, Alma L., Fainzilber, Mike
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501578/
https://ncbi.nlm.nih.gov/pubmed/29567716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan1053
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