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Epstein–Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth

By binding to a cis-acting element (oriP) in the Epstein–Barr virus (EBV) genome, EBV nuclear antigen 1 (EBNA1) enables persistence and enhances transcription from EBV episomes. To investigate whether EBNA1 also directly affects cell gene transcription, we conditionally expressed a Flag-tagged domin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kang, Myung-Soo, Hung, Siu Chun, Kieff, Elliott
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC65012/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11734622/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211556598
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