The role of the third β strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012

Neutralization of HIV-1 primary isolates has been a tremendous challenge for AIDS vaccine development. Here, we identify a single amino acid change (T198P) in gp120 that alters the neutralization sensitivity of the primary isolate DH012 to antibodies against multiple neutralization epitopes that inc...

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Библиографические подробности
Главные авторы: Zhu, Chong-Bin, Zhu, Lei, Holz-Smith, Sonia, Matthews, Thomas J., Chen, Chin Ho
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2001
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC65011/
https://ncbi.nlm.nih.gov/pubmed/11734627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261359098
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