Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents

The bromodomain‐containing protein 7 (BRD7) is a tumour suppressor protein with critical roles in cell cycle transition and transcriptional regulation. Whether BRD7 is regulated by post‐translational modifications remains poorly understood. Here, we find that chemotherapy‐induced DNA damage leads to...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Hu, Kaishun, Wu, Wenjing, Li, Yu, Lin, Lehang, Chen, Dong, Yan, Haiyan, Xiao, Xing, Chen, Hengxing, Chen, Zhen, Zhang, Yin, Xu, Shuangbing, Guo, Yabin, Koeffler, H Phillip, Song, Erwei, Yin, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500972/
https://ncbi.nlm.nih.gov/pubmed/30940648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846166
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