Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents

The bromodomain‐containing protein 7 (BRD7) is a tumour suppressor protein with critical roles in cell cycle transition and transcriptional regulation. Whether BRD7 is regulated by post‐translational modifications remains poorly understood. Here, we find that chemotherapy‐induced DNA damage leads to...

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Veröffentlicht in:EMBO Rep
Hauptverfasser: Hu, Kaishun, Wu, Wenjing, Li, Yu, Lin, Lehang, Chen, Dong, Yan, Haiyan, Xiao, Xing, Chen, Hengxing, Chen, Zhen, Zhang, Yin, Xu, Shuangbing, Guo, Yabin, Koeffler, H Phillip, Song, Erwei, Yin, Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500972/
https://ncbi.nlm.nih.gov/pubmed/30940648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846166
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