Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress

α-Tocopherol transfer protein (α-TTP) maintains the concentration of serum α-tocopherol (vitamin E), one of the most potent fat-soluble antioxidants, by facilitating α-tocopherol export from the liver. Mutations of the α-TTP gene are linked to ataxia with isolated vitamin E deficiency (AVED). We pro...

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Bibliografiske detaljer
Main Authors: Yokota, Takanori, Igarashi, Keiji, Uchihara, Toshiki, Jishage, Kou-ichi, Tomita, Hiroshi, Inaba, Akira, Li, Yi, Arita, Makoto, Suzuki, Hiroshi, Mizusawa, Hidehiro, Arai, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC65004/
https://ncbi.nlm.nih.gov/pubmed/11752462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261456098
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