DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

BACKGROUND: Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and color...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Weigel, Christoph, Chaisaingmongkol, Jittiporn, Assenov, Yassen, Kuhmann, Christine, Winkler, Volker, Santi, Irene, Bogatyrova, Olga, Kaucher, Simone, Bermejo, Justo L., Leung, Suet Y., Chan, Tsun L., Lasitschka, Felix, Bohrer, Manfred H., Marx, Alexander, Haußen, Roland Heyny-von, Herold-Mende, Christel, Dyckhoff, Gerhard, Boukamp, Petra, Delank, Klaus W., Hörmann, Karl, Lippert, Burkhard M., Baier, Gerald, Dietz, Andreas, Oakes, Christopher C., Plass, Christoph, Becher, Heiko, Schmezer, Peter, Ramroth, Heribert, Popanda, Odilia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499986/
https://ncbi.nlm.nih.gov/pubmed/31053176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0666-5
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