Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Haematopoietic stem cells (HSCs) are maintained by bone marrow (BM) niches in vivo(1,2), but the ability of niche cells to maintain HSCs ex vivo is markedly diminished. Expression of niche factors by Nestin-GFP(+) mesenchymal-derived stromal cells (MSCs) is downregulated upon culture, suggesting tha...

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Pubblicato in:Nat Cell Biol
Autori principali: Nakahara, Fumio, Borger, Daniel K., Wei, Qiaozhi, Pinho, Sandra, Maryanovich, Maria, Zahalka, Ali H., Suzuki, Masako, Cruz, Cristian D., Wang, Zichen, Xu, Chunliang, Boulais, Philip E., Ma'ayan, Avi, Greally, John M., Frenette, Paul S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499646/
https://ncbi.nlm.nih.gov/pubmed/30988422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0308-3
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