Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Haematopoietic stem cells (HSCs) are maintained by bone marrow (BM) niches in vivo(1,2), but the ability of niche cells to maintain HSCs ex vivo is markedly diminished. Expression of niche factors by Nestin-GFP(+) mesenchymal-derived stromal cells (MSCs) is downregulated upon culture, suggesting tha...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Cell Biol
Egile Nagusiak: Nakahara, Fumio, Borger, Daniel K., Wei, Qiaozhi, Pinho, Sandra, Maryanovich, Maria, Zahalka, Ali H., Suzuki, Masako, Cruz, Cristian D., Wang, Zichen, Xu, Chunliang, Boulais, Philip E., Ma'ayan, Avi, Greally, John M., Frenette, Paul S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499646/
https://ncbi.nlm.nih.gov/pubmed/30988422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0308-3
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