Immunotherapeutic effects of intratumoral nanoplexed poly I:C

Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed with polyethylenimine that causes tumor cell apoptosis showing immunogenic cell death features and which upon intratumoral release results i...

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Publicat a:J Immunother Cancer
Autors principals: Aznar, M. Angela, Planelles, Lourdes, Perez-Olivares, Mercedes, Molina, Carmen, Garasa, Saray, Etxeberría, Iñaki, Perez, Guiomar, Rodriguez, Inmaculada, Bolaños, Elixabet, Lopez-Casas, Pedro, Rodriguez-Ruiz, Maria E., Perez-Gracia, Jose L., Marquez-Rodas, Ivan, Teijeira, Alvaro, Quintero, Marisol, Melero, Ignacio
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498680/
https://ncbi.nlm.nih.gov/pubmed/31046839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0568-2
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