Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells

BACKGROUND: GMEB1 was originally identified via its interaction with GMEB2, which binds to the promoter region of the tyrosine aminotransferase (TAT) gene and modulates transactivation of the glucocorticoid receptor gene. In the cytosol, GMEB1 interacts with and inhibits CASP8, but the molecular mec...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: An, Wentao, Yao, Shun, Sun, Xiaoyang, Hou, Zhaoyuan, Lin, Yidan, Su, Ling, Liu, Xiangguo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498657/
https://ncbi.nlm.nih.gov/pubmed/31046799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1182-3
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