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K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function
Ras genes potently drive human cancers, with mutated proto-oncogene GTPase KRAS4B (K-Ras4B) being the most abundant isoform. Targeted inhibition of oncogenic gene products is considered the “holy grail” of present-day cancer therapy, and recent discoveries of small-molecule KRas4B inhibitors were ma...
Sparad:
| I publikationen: | J Biol Chem |
|---|---|
| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6497929/ https://ncbi.nlm.nih.gov/pubmed/30792310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004021 |
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