TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

Mutations in the polycystins cause autosomal dominant polycystic kidney disease (ADPKD). Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel polycystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range...

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Udgivet i:Nat Commun
Main Authors: Arhatte, Malika, Gunaratne, Gihan S., El Boustany, Charbel, Kuo, Ivana Y., Moro, Céline, Duprat, Fabrice, Plaisant, Magali, Duval, Hélène, Li, Dahui, Picard, Nicolas, Couvreux, Anais, Duranton, Christophe, Rubera, Isabelle, Pagnotta, Sophie, Lacas-Gervais, Sandra, Ehrlich, Barbara E., Marchant, Jonathan S., Savage, Aaron M., van Eeden, Fredericus J. M., Wilkinson, Robert N., Demolombe, Sophie, Honoré, Eric, Patel, Amanda
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497644/
https://ncbi.nlm.nih.gov/pubmed/31048699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10045-y
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