Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels

How renal epithelial cells respond to increased pressure and the link with kidney disease states remain poorly understood. Pkd1 knock out or expression of a PC2 pathogenic mutant, mimicking the autosomal dominant polycystic kidney disease, dramatically enhances mechanical stress-induced tubular apop...

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Detalhes bibliográficos
Main Authors: Peyronnet, Rémi, Sharif-Naeini, Reza, Folgering, Joost H.A., Arhatte, Malika, Jodar, Martine, Boustany, Charbel El, Gallian, Claire, Tauc, Michel, Duranton, Christophe, Rubera, Isabelle, Lesage, Florian, Pei, York, Peters, Dorien J.M., Somlo, Stefan, Sachs, Frederick, Patel, Amanda, Honoré, Eric, Duprat, Fabrice
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437542/
https://ncbi.nlm.nih.gov/pubmed/22832196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.01.006
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