CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons

Patient-specific induced pluripotent stem cells (iPSCs) are a powerful tool to investigate the molecular mechanisms underlying Parkinson’s disease (PD), and might provide novel platforms for systematic drug screening. Several strategies have been developed to generate iPSC-derived tyrosine hydroxyla...

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Publicado no:Sci Rep
Main Authors: Calatayud, Carles, Carola, Giulia, Fernández-Carasa, Irene, Valtorta, Marco, Jiménez-Delgado, Senda, Díaz, Mònica, Soriano-Fradera, Jordi, Cappelletti, Graziella, García-Sancho, Javier, Raya, Ángel, Consiglio, Antonella
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497635/
https://ncbi.nlm.nih.gov/pubmed/31048719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43080-2
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