Myc and loss of p53 cooperate to drive formation of choroid plexus carcinoma

Choroid plexus carcinoma (CPC) is a rare brain tumor that occurs most commonly in very young children and has a dismal prognosis despite intensive therapy. Improved outcomes for CPC patients depend on a deeper understanding of the mechanisms underlying the disease. Here we developed transgenic model...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Wang, Jun, Merino, Diana M., Light, Nicholas, Murphy, Brian L., Wang, Yong-Dong, Guo, Xiaohui, Hodges, Andrew P., Chau, Lianne Q., Liu, Kun-Wei, Dhall, Girish, Asgharzadeh, Shahab, Kiehna, Erin N., Shirey, Ryan J., Janda, Kim D., Taylor, Michael D., Malkin, David, Ellison, David W., VandenBerg, Scott R., Eberhart, Charles G., Sears, Rosalie C., Roussel, Martine F., Gilbertson, Richard J., Wechsler-Reya, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497574/
https://ncbi.nlm.nih.gov/pubmed/30885981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2565
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